2016 Annual Retreat

Every Spring the RBC hosts an Annual Retreat at Eugene T. Mahoney State Park. The retreat is a opportunity for students to present their research and receive feedback from faculty members.

The 2016 Redox Biology Center Annual Retreat at Eugene T. Mahoney State Park will be held on April 15-16,  2016. This year's retreat will feature a poster session, scientific presentations by students and postdoctoral associates, and a plenary lecture by Dr. Dennis Winge, Professor of Internal Medicine and Research-Professor of Biochemistry at The University of Utah, Salt Lake City.


Research in the Winge laboratory is focused on cellular mitochondria. One major focus is the biogenesis of the mitochondrial electron transfer respiratory complexes II, III and IV within this organelle. Improper assembly of these complexes are evident in inherited and acquired diseases of patients with cardiomyopathy, hepatopathy, and neurological disorders. A key step in assembly of these complexes is the formation of their essential flavin, heme, and iron-sulfur centers, which are inserted by the involvement of assembly factor proteins. Much of the current knowledge on the biogenesis of theses respiratory complexes was elucidated in Saccharomyces cerevisiae, and many of the known assembly factors are conserved in in humans.

We seek to identify new proteins that mediate the biogenesis of succinate dehydrogenase, cytochrome c reductase and cytochrome  c oxidase complexes and elucidate their mechanism of action. We use a combination of in vitro biochemical, in vivo cellular assays and genetic analyses in these pursuits. Specifically, we are studying how flavin and three iron-sulfur centers are formed in succinate dehydrogenase, how the heme andiron-sulfur centers are formed in cytochrome c reductase and the pathway ofcopper and heme a center formation in cytochrome oxidase. In these studies we are focused on known assembly factors as well as seeking novel factors that mediate formation of the redox centers.

Past Keynote Speakers

2015: Dr. Holly Van Remmen, PhD, Senior Research Scientist Free Radical Biology and Aging Program, Full Member of the Oklahoma Medical Research Foundation ,Oklahoma City

2014: Dr. Tohru Fukai, Associate Professor, Department of Medicine and Pharmacology, University of Illinois at Chicago

2013: Dr. Jim Imlay, Professor, Department of Microbiology, University of Illinois at Urbana-Champaign

2012: Dr. Henry Jay Forman, Professor of Biochemistry and Chemistry at the University of California, Merced

2011: Dr. Frederick (Rick) Domann, Professor of Radiation Oncology in the Free Radical and Radiation Biology Program at the University of Iowa