2014 Annual Retreat
Dr. Jaekwon Lee hosted the 2014 Redox Biology Center Annual Retreat at Eugene T. Mahoney State Park, April 4-5, 2014. This year's retreat featured two poster sessions, scientific presentations by students, postdoctoral associates and faculty and feature Tohru Fukai, MD, PhD, Associate Professor of Medicine and Pharmacology at the University of Illinois College of Medicine at Chicago.
Dr. Tohru Fukai's lab has been investigating a role of oxidative stress and copper (Cu) transport system in cardiovascular disease. They provided the first evidence that Cu transport proteins, such as antioxidant-1 (Atox1) and/or Menkes protein (ATP7A) protect against endothelial dysfunction induced by hypertension and diabetes by regulating activity of Cu containing antioxidant enzyme, extracellular superoxide dismutase (ecSOD). Recently, Dr. Fukai's lab found that Atox1 is upregulated in atherosclerotic vessels and functions as a Cu-dependent transcription factor to regulate cell proliferation. Moreover, they showed that Atox1 and ATP7A are required for vascular migration and neointimal formation in vascular injury model, and that Atox1 is involved in inflammatory responses. These findings provide novel insights into Cu transport proteins and its regulators as potential therapeutic targets for oxidative stress- and inflammation-dependent cardiovascular and metabolic diseases.
Past Keynote Speakers
2013: Dr. Jim Imlay, Professor, Department of Microbiology, University of Illinois at Urbana-Champaign
2012: Dr. Henry Jay Forman, Professor of Biochemistry and Chemistry at the University of California, Merced
2011: Dr. Frederick (Rick) Domann, Professor of Radiation Oncology in the Free Radical and Radiation Biology Program at the University of Iowa