Redox Biology Center Pilot Project Program
The overall goal of the research pilot program is to promote interdisciplinary and multi-institution collaborations that address novel questions in redox biology and impact human health and disease. The on-going research pilot program has been very successful, investing in early-stage career faculty and providing seed funding for innovative research ideas and collaborative projects that have led to the development of extramural awards totaling over $5M.
Requests for applications for the pilot program stress the goals of the RBC and emphasize the need for collaborative and innovative research proposals that address important areas in redox biology (e.g., pathogenesis and stress response, redox signaling, mitochondrial dysfunction, metal ion homeostasis). A rigorous review process is in place to ensure that the RBC selects projects that are highly meritorious and those that are most likely to generate key preliminary data to successfully compete for external funding. The pilot program seeks to fund teams of RBC investigators from the University of Nebraska-Lincoln (UNL) and the University of Nebraska Medical Center (UNMC) that are pursuing joint research proposals (e.g., collaborative R01 project proposals and program projects).
The following projects were selected for funding in 2014.
"Emerging regulatory paradigms in glutathione metabolism during cancer" - Joe Barycki (PI), Melanie Simpson, Jiantao Guo
"Peroxidase-mediate nitration of the Pseudomonas aeruginosa quinolone signal compound (PQS):biochemistry and possible role in cystic fibrosis lung injury" - Maher Abdalla (PI), Brad Britigan, Matthew Zimmerman, Iman Ahmad, Javier Seravalli
"New anti-superbug strategy-using small molecule signaling factors to increase the susceptibility of bacteria to existing antibiotics" - Liangcheng Du (PI), Robert Powers, Greg Somerville