Sun Lab Publications

Selected Publications

PubMed Articles

2021

  1. Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis A, Sun X, Sukhova GK, Welt F, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW. Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans. Arterioscler Thromb Vasc Biol. 2021 Feb 11:ATVBAHA121315896. doi: 10.1161/ATVBAHA.121.315896. Online ahead of print. PMID: 33567868.
  2. Cheng X, Shihabudeen Haider Ali MS, Moran M, Viana MP, Schlichte SL, Zimmerman MC, Khalimonchuk O, Feinberg MW, Sun X. Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Redox Biol. 2021 Jan 19;40:101863. doi: 10.1016/j.redox.2021.101863. Online ahead of print. PMID: 33508742.
  3. Yang D, Haemmig S, Zhou H, Pérez-Cremades D, Sun X, Chen L, Li J, Haneo-Mejia J, Yang T, Hollan I, Feinberg MW. Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway. Elife. 2021 Jan 8;10:e58064. doi: 10.7554/eLife.58064. PMID: 33416495.

2020

  1. Kim H, Jeon BT, Kim IM, Bennett SJ, Lorch CM, Viana MP, Myers JF, Trupp CJ, Whipps ZT, Kundu M, Chung S, Sun X, Khalimonchuk O, Lee J, Ro SH. Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress. Int J Mol Sci. 2020 Aug 25;21(17):6130. PMID: 32854424.
  2. Sun X, Harris EN. New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease.  Am J Physiol Cell Physiol. 2020 Jun 1;318(6):C1200-C1213. PMID: 32374676 Review.
  3. Arumugam R, Yalaka B, Massilamany C, Haider Ali MSS, Lasrado N, Jayaraja S, Riethoven JJ, Sun X, Reddy J. An evidence for surface expression of an immunogenic epitope of sarcoplasmic/endoplasmic reticulum calcium-ATPase2a on antigen-presenting cells from naive mice in the mediation of autoimmune myocarditis. Immunobiology. 2020 Mar;225(2):151896. PMID: 31870642
  4. Haemmig S, Yang D, Sun X, Das D, Ghaffari S, Molinaro R, Chen L, Deng Y, Freeman D, Moullan N, Tesmenitsky Y, Wara AKMK, Simion V, Shvartz E, Lee JF, Yang T, Sukova G, Marto JA, Stone PH, Lee WL, Auwerx J, Libby P, Feinberg MW. Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. Sci Transl Med. 2020 Feb 19;12(531). pii: eaaw1868. doi:10.1126/scitranslmed.aaw1868. PubMed PMID: 32075942.

2019

  1. Moran M, Cheng X, Shihabudeen Haider Ali MS, Wase N, Nguyen N, Yang W, Zhang C, DiRusso C, Sun X. Transcriptome analysis-identified long noncoding RNA CRNDE in maintaining endothelial cell proliferation, migration, and tube formation. Sci Rep. 2019 Dec 20;9(1):19548. doi: 10.1038/s41598-019-56030-9. PubMed PMID: 31863035; PubMed Central PMCID: PMC6925215.
  2. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic Acids Res. 2019 Feb 20;47(3):1505-1522. doi:10.1093/nar/gky1190. PubMed PMID: 30476192; PubMed Central PMCID: PMC6379667.

2017

  1. Sun X*, Haider Ali MSS, Moran M. The role of interactions of long non-coding RNAs and heterogeneous nuclear ribonucleoproteins in regulating cellular functions. Biochem J. 2017 Aug 11;474(17):2925-2935. doi: 10.1042/BCJ20170280. Review. PubMed PMID: 28801479; PubMed Central PMCID: PMC5553131. *, Corresponding author.
  2. Zhang Y, Sun X, Icli B, Feinberg MW. Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy. Endocr Rev. 2017 Apr 1;38(2):145-168. doi: 10.1210/er.2016-1122. Review. PubMed PMID: 28323921; PubMed Central PMCID: PMC5460677.

2016 and Before

  1. Sun X*, Wong D. Long non-coding RNA-mediated regulation of glucose homeostasis and diabetes. Am J Cardiovasc Dis. 2016 May 18;6(2):17-25. eCollection 2016. Review. PubMed PMID: 27335687; PubMed Central PMCID: PMC4913211. *, Corresponding author.
  2. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. FASEB J. 2016 Sep;30(9):3216-26. doi: 10.1096/fj.201500163R. Epub 2016 Jun 13. PubMed PMID: 27297585; PubMed Central PMCID: PMC5001512.
  3. Sun X, Lin J, Zhang Y, Kang S, Belkin N, Wara AK, Icli B, Hamburg NM, Li D, Feinberg MW. MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue. Circ Res. 2016 Mar 4;118(5):810-21. doi: 10.1161/CIRCRESAHA.115.308166. Epub 2016 Jan 7. PubMed PMID: 26830849; PubMed Central PMCID: PMC4779381.
  4. Icli B, Nabzdyk CS, Lujan-Hernandez J, Cahill M, Auster ME, Wara AK, Sun X, Ozdemir D, Giatsidis G, Orgill DP, Feinberg MW. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a. J Mol Cell Cardiol. 2016 Feb;91:151-9. doi: 10.1016/j.yjmcc.2016.01.007. Epub 2016 Jan 9. PubMed PMID: 26776318; PubMed Central PMCID: PMC4764471.
  5. Andreou I, Sun X, Stone PH, Edelman ER, Feinberg MW. miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends Mol Med. 2015 May;21(5):307-18. doi: 10.1016/j.molmed.2015.02.003. Epub 2015 Mar 11. Review. PubMed PMID: 25771097; PubMed Central PMCID: PMC4424146.
  6. Khedkar SA*, Sun X*, Rigby AC, Feinberg MW. Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation. J Med Chem. 2015 Feb 12;58(3):1466-78. doi: 10.1021/jm5018187. Epub 2015 Feb 4. PubMed PMID: 25581017; PubMed Central PMCID: PMC4811605. *, equal contribution.
  7. Sun X, Feinberg MW. Regulation of endothelial cell metabolism: just go with the flow. Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):13-5. doi: 10.1161/ATVBAHA.114.304869. PubMed PMID: 25520522; PubMed Central PMCID: PMC4273666.
  8. Sun X, Feinberg MW. MicroRNA-management of lipoprotein homeostasis. Circ Res. 2014 Jun 20;115(1):2-6. doi: 10.1161/CIRCRESAHA.114.304228. PubMed PMID: 24951757; PubMed Central PMCID: PMC4083235.
  9. Sun X, Sit A, Feinberg MW. Role of miR-181 family in regulating vascular inflammation and immunity. Trends Cardiovasc Med. 2014 Apr;24(3):105-12. doi: 10.1016/j.tcm.2013.09.002. Epub 2013 Nov 1. Review. PubMed PMID: 24183793; PubMed Central PMCID: PMC3943593.
  10. Sun X, Belkin N, Feinberg MW. Endothelial microRNAs and atherosclerosis. Curr Atheroscler Rep. 2013 Dec;15(12):372. doi: 10.1007/s11883-013-0372-2. Review. PubMed PMID: 24158362; PubMed Central PMCID: PMC3859467.
  11. Sun X, He S, Wara AKM, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW. Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res. 2014 Jan 3;114(1):32-40. doi: 10.1161/CIRCRESAHA.113.302089. Epub 2013 Oct 1. PubMed PMID: 24084690; PubMed Central PMCID: PMC4051320.
  12. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013 Nov 8;113(11):1231-41. doi: 10.1161/CIRCRESAHA.113.301780. Epub 2013 Sep 18. PubMed PMID: 24047927; PubMed Central PMCID: PMC4068743.
  13. Wara AK, Manica A, Marchini JF, Sun X, Icli B, Tesmenitsky Y, Croce K, Feinberg MW. Bone marrow-derived Kruppel-like factor 10 controls reendothelialization in response to arterial injury. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1552-60. doi: 10.1161/ATVBAHA.112.300655. Epub 2013 May 16. PubMed PMID: 23685559; PubMed Central PMCID: PMC3835145.
  14. Sun X, Feinberg MW. NF-κB and hypoxia: a double-edged sword in atherosclerosis. Am J Pathol. 2012 Nov;181(5):1513-7. doi: 10.1016/j.ajpath.2012.09.001. Epub 2012 Sep 20. PubMed PMID: 22999810; PubMed Central PMCID: PMC3483811.
  15. Sun X, Feinberg MW. Knocking out viral myocarditis: reality or a miRage? Circ Res. 2012 Aug 3;111(4):388-91. doi: 10.1161/CIRCRESAHA.112.275214. PubMed PMID: 22859666; PubMed Central PMCID: PMC3426925.
  16. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP; MICU Registry, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-κB-mediated vascular inflammation. J Clin Invest. 2012 Jun;122(6):1973-90. doi: 10.1172/JCI61495. Epub 2012 May 24. PubMed PMID: 22622040; PubMed Central PMCID: PMC3366408.
  17. Wara AK, Foo S, Croce K, Sun X, Icli B, Tesmenitsky Y, Esen F, Lee JS, Subramaniam M, Spelsberg TC, Lev EI, Leshem-Lev D, Pande RL, Creager MA, Rosenzweig A, Feinberg MW. TGF-β1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization. Blood. 2011 Dec 8;118(24):6450-60. doi: 10.1182/blood-2011-06-363713. Epub 2011 Aug 9. PubMed PMID: 21828131; PubMed Central PMCID: PMC3236126.
  18. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011 Sep;121(9):3564-77. doi: 10.1172/JCI46028. Epub 2011 Aug 8. Erratum in: J Clin Invest. 2018 Nov 1;128(11):5184. PubMed PMID: 21821913; PubMed Central PMCID: PMC3163955.
  19. Cao Z, Sun X, Icli B, Wara AK, Feinberg MW. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood. 2010 Nov 25;116(22):4404-14. doi: 10.1182/blood-2010-05-285353. Epub 2010 Jul 8. Review. PubMed PMID: 20616217; PubMed Central PMCID: PMC2996110.
  20. Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11;284(37):24914-24. doi: 10.1074/jbc.M109.000059. Epub 2009 Jul 14. PubMed PMID: 19602726; PubMed Central PMCID: PMC2757194.
  21. Fang K, Fu W, Beardsley AR, Sun X, Lisanti MP, Liu J. Overexpression of caveolin-1 inhibits endothelial cell proliferation by arresting the cell cycle at G0/G1 phase. Cell Cycle. 2007 Jan 15;6(2):199-204. Epub 2007 Jan 20. PubMed PMID: 17245131.
  22. Wang X, Li P, Zhang YQ, Hou M, Sun XH, Tan L, Zhu YS. [Biological function of fusion protein ATF-PAI2CD]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Jul;35(7):624-8. Chinese. PubMed PMID: 12883632.
  23. Sun XH, Tan L, Li CY, Tong C, Fan J, Li P, Zhu YS. A novel gene delivery system targeting urokinase receptor. Acta Biochim Biophys Sin (Shanghai). 2004 Jul;36(7):485-91. PubMed PMID: 15248023.
  24. Sun XH, Flynn DC, Castranova V, Millecchia LL, Beardsley AR, Liu J. Identification of a novel domain at the N terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation. J Biol Chem. 2007 Mar 9;282(10):7232-41. Epub 2007 Jan 8. PubMed PMID: 17213184.
  25. Sun XH, Liu ZY, Chen H, Beardsley AR, Qi Q, Liu J. A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration. FEBS Lett. 2009 Nov 19;583(22):3681-9. doi:10.1016/j.febslet.2009.10.055. Epub 2009 Oct 23. PubMed PMID: 19854179.

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/xinghui.sun.1/bibliography/47531328/public/