Jay Reddy, MVSc, PhD

Jay Reddy, MVSc, PhD
Associate Professor
Department of Veterinary and Biomedical Sciences
Room 202, East Campus
University of Nebraska-Lincoln
Lincoln, NE 68583

Phone: (402) 472-8541
Fax: (402) 472-9690
E-mail: nreddy2@unl.edu
Website: http://jayreddy.unl.edu/

  

Research Description:

Our long-term interest is the cellular and molecular mechanisms underlying the development of human autoimmune diseases. Most healthy humans have a propensity to develop autoimmune diseases, as evidenced by the presence of autoreactive T cells or autoantibodies in their naïve periphery. T cells are educated in the thymus, where high-affinity TCR-bearing cells that interact with self-antigens are deleted by negative selection while T cells with low-affinity TCR to self-antigens are selected positively and exported to the periphery. In spite of the high frequency of self-reactive T cells in the naïve peripheral repertoires, autoimmune responses do not ensue spontaneously. How this tolerance is maintained is a fundamental question. We focus our investigations on the role of reactive oxygen species in the maintenance of T cell tolerance and autoimmunity.