Research Focus

• Tyrosine phosphorylation and Redox signal transduction in androgen regulation of cell proliferation and carcinogenesis
• Prostate cancer
• Molecular oncogenesis
• Tyrosine phosphorylation & dephosphorylation
• Redox signaling
• Steroid hormone action
• Translational research

Current Projects

• Protein Tyrosine Phosphorylation signaling
• Redox signaling
• Two US Patent-awarded Prostate Cancer Cell Progression Models
• Small Molecule Analyses

For translational applications, our approaches include various molecular and cellular approaches, e.g., global proteomic and phospho-proteomic array analyses, in conjunction with xenograft animal models and clinical archival specimens. We will obtain information necessary for a better understanding in various aspects of androgen effects on prostate cancer biology. For immediate clinical applications, we investigate the development of novel therapeutic approaches including novel chemo-reagents applicable for the cases refractory to hormonal therapy of the advanced cancer.