Jaekwon Lee, PhD

Research Description:

The research program in my laboratory focuses on understanding mechanisms of nutritional and toxic metal metabolism, and molecular basis of defective metal metabolism in diseases. All living organisms have developed delicate mechanisms for uptake, distribution, incorporation, and excretion of essential metals to acquire sufficient levels without toxic accumulation. Defense systems against toxicity of physiological and non-physiological metals are also vital for life. We have identified membrane transporters through which eukaryotes (including baker's yeast, mice, and humans) uptake or export copper (an essential yet toxic micronutrient) or cadmium (an ubiquitous toxic metal). Characterization of mechanisms of action and regulation of the transporters will provide new insights about how organisms control cellular metal accumulation. These studies are important in developing better strategies for combating metals and reactive oxygen species-mediated various human diseases.